Kara Maxwell, MD, PhD, director of our Men & BRCA program, worked with CureBRCA to publish a new paper that compiles various approved guidelines for men with BRCA mutations, including statistical tables that compare the risks of certain cancers for men with BRCA1 and BRCA2 genetic mutations.

Ronny Drapkin, MD, PhD, director of the Penn Ovarian Cancer Research Center and director of Gynecologic Cancer Research in the Basser Center for BRCA, discussed why it’s difficult to detect ovarian cancer in its earliest stages and how new drugs like PARP inhibitors have made a difference in ovarian cancer treatment.

Susan Domchek, MD, director of the Basser Center for BRCA, discussed her path to breast cancer genetics research and how the Basser Center is working to improve care and future outcomes for people with a family history of cancer, including carriers of BRCA gene mutations, which increase an individual’s risk of developing certain cancers.

Cancer vaccines have been a dream for decades, but researchers are making progress, as evidenced in a variety of ongoing clinical trials, including one led by executive director Susan Domchek, MD. “Getting involved in clinical trials is of the utmost importance if we want to change the trajectory of difficult-to-treat diseases,” said Filko Prugo, a BRCA2 mutation carrier who is participating in the Basser trial.

Kara Maxwell, MD, PhD, director of the Basser Center's Men & BRCA program, discussed research her team presented at the 2024 AACR Annual Meeting, including strategies to optimize genetic testing to better inform decision-making in prostate cancer treatment and the prevalence of germline mutations in racially diverse cohorts of patients with metastatic prostate cancer.

The clinical utilization of genetic testing in metastatic prostate cancer cases is rising. Kara Maxwell, MD, PhD, discusses research on genetic testing results in metastatic prostate cancer patients and results of prostate cancer genetic testing in diverse populations.

DNA replication—which happens when cells divide—is one of the most important processes in all living organisms. In a landmark finding, scientists identified a multi-protein “machine” in cells that helps govern the pausing of this process. The study was led by Roger Greenberg, MD, PhD, Basser Center director of Basic Science.

Susan M. Domchek, MD, Basser Center executive director, and Robert H. Vonderheide, MD, DPhil, director of the ACC, report on cancer interception development with rapid advances in technology, therapeutics, and genetic testing methods.

Stacey Sager shares a series of stories as she takes us through her own courageous and challenging health journey as a BRCA1 gene mutation carrier, featuring Dr. Susan Domchek, the executive director at the Basser Center.

Susan Domchek, MD, executive director of the Basser Center, discusses the latest updates in the race for a cancer prevention vaccine that could benefit individuals and families carrying a BRCA1 or BRCA2 genetic mutation.

A groundbreaking cancer vaccine is in the midst of clinical trials at the Basser Center. The shot would benefit those carrying cancer-causing BRCA gene mutations by recognizing the earliest signs of disease and stopping cancer before it develops.