Our laboratory focuses on understanding the origins and progression of BRCA-associated ovarian cancers, with a particular emphasis on the fallopian tube epithelium as the likely cell of origin. Using a suite of innovative model systems—including genetically engineered mice, fallopian tube–derived cell lines, and patient-derived xenografts—we investigate how genetic alterations such as BRCA mutations drive tumor development and how the tumor microenvironment shapes disease progression. Recently, we have used mouse models to uncover new components of the microenvironment, including tumor-associated sensory nerves, that actively promote ovarian cancer growth and metastasis. In parallel, we are leading efforts to develop a comprehensive “pre-cancer atlas” that charts the earliest molecular and cellular changes preceding malignancy. Together, these approaches aim to identify new opportunities for early detection and cancer interception, while providing a deeper biological framework for developing more effective therapies.