POSTER 1

A Single-Cell Spatial Proteomic Analysis of the TNBC Microenvironment Defines Genotype-Specific Features
 

Dana Pueschl, PhD (1); Danielle Bragen, M.S. (1); Jia-Ren Lin, PhD (2); Nagendra Yarla, PhD (3); Anupma Nayak, MD (4); Kurt D'Andrea, BS (1); Victoria Fang, MD, PhD (5); Derek Oldridge, MD, PhD (6); Kate Bennett, BS (7); kConFab Investigators (8); Kenneth Offit, MD, MPH (9,10); Andrew K. Godwin, PhD (11,12); Paul A. James, MD (13,14); Phuong L. Mai, MD (15); Soo Hwang Teo, PhD (16); Antonis Antoniou, PhD (17); Georgia Chenevix-Trench, PhD (18); E. John Wherry, PhD (5,19,20); Susan M. Domchek, MD (21,22); Katherine L. Nathanson, MD (1,21,22)
 

^{(1) Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USA
(2) Laboratory of Systems Pharmacology, Harvard Medical School, Boston, USA
(3) Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, USA
(4) Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA
(5) Institute for Immunology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA
(6) Center for Computational and Genomic Medicine, The Children's Hospital of Philadelphia, USA
(7) Gastroenterology Division, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA
(8) Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Research Department, Peter MacCallum Cancer Centre, Melbourne, Australia
(9) Niehaus Center for Inherited Cancer Genomics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, USA
(10) Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
(11) Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, USA
(12) Kansas Institute for Precision Medicine, University of Kansas Medical Center, Kansas   City, USA
(13) Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia
(14) Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia
(15) Magee‐Womens Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
(16) Breast Cancer Research Program, Cancer Research Malaysia, Malaysia 
(17) Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
(18) Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
(19) Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 
(20) Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Perelman School of Medicine, Philadelphia, USA
(21) Abramson Cancer Center, University of Pennsylvania, Philadelphia, USA   
(22) Basser Center for BRCA, University of Pennsylvania, Philadelphia, USA}

POSTER 2

Targeting Neoantigens Associated with BRCA1/2 Reversion Mutations in PARP Inhibitor and Platinum-Resistant Breast Cancer
 

Dr Gonzalo Torga (1,2), Dr Lauren Dawson (1), Dr Rebeca Uceda-Castro (1), Dr Lorena Magraner-Pardo (1), Dr Asha Konte (1), Rachel Alcraft (3), Dr Stephen J. Pettitt (1), Professor Christopher J. Lord (1), Professor Andrew N. J. Tutt (1,2)
 

^{(1) The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK  
(2) Breast Cancer Now Research Unit and School of Cancer and Pharmaceutical Sciences, King's College London, London, UK
(3) Scientific Computing, The Institute of Cancer Research, London, UK}

POSTER 3

Base Editing Screens to Identify Druggable Vulnerabilities in BRCA Mutant Cancers
 

Tao Shi (1), Diqiu Ren (2), Sanim Rahman (1), Kaitlyn Toy (1), Junwei Shi (2), Roger Greenberg (1)
 

^{(1) Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
(2) Department of Cancer Biology, Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.}

POSTER 4

Identifying Immune Mediators in Ovarian Cancer
 

Taku Harada(1), Katherine Cummins (2), Matthew Knarr (2), Ronny Drapkin (2), Roger Greenberg (1)
 

^{(1) Department of Cancer Biology, University of Pennsylvania 
(2) Penn Ovarian Cancer Research Center}

POSTER 5

Defining the Early Replication Stress Signatures of BRCA1 Mutant Ovarian Cancers
 

Sierra Wallace (1), Courtney Jungers (1), Mujeeb Pirzada (2), Ellis Chalfant (1), Danielle Kemper (1), Priyanka Verma (1), John Krais (1), Mary Mullen (1), Sergej Djuranovic (2), Alessandro Vindigni (1)
 

^{(1) Washington University School of Medicine, Saint Louis, MO 63110, USA
(2) Brown University, Providence, RI 02912, USA}

POSTER 6

BRCA2-Associated Target Engagement and Immune-Relevant Responses to PARP-Targeted Alpha Therapy in Ovarian Cancer Models
 

Mingyu Zhang (1), Alastair McArthur (1), Aladdin Riad (1), Sai Preethi Nakkina (1), Michael D. Farwell (1), Sarah B. Gitto (1)
 

^{(1) Department of Radiology, Perelman School of Medicine, University of Pennsylvania}

POSTER 7

Platform to Study DNA Damage Response Inhibitor (DDRi) Resistance and Identify Biomarkers of Response to New Therapies for BRCA1/2 Mutant Ovarian Cancers
 

Amaryllis Ortiz (1), Ian Heller (1), Yawei Hu (1), Kristy Ma (3), Matthew Anderson (1), Sergey Medvedev (1), Xiaoyin Shan (1), Haineng Xu (1), Changfeng Zhao (1), Xiaolei Wang (1), Eric Brown (2), Dan Powell (3,) Hyoung Kim (1), Fiona Simpkins (1)
 

^{(1) Dept. of OB-GYN, University of Pennsylvania
(2) Dept. of Cancer Biology, University of Pennsylvania
(3) Dept. of Pathology and Laboratory Medicine, University of Pennsylvania}

POSTER 8

Decoding the Molecular Landscape of BRCA1/2-Associated Prostate Cancer
 

Taylor Crawford (1,2), Nabamita Boruah PhD (1), Ryan Hausler (1), Emily Scarrow (1,2), Meredith Davies (3), Evelyn Milavsky (1,2), Greg Kelly (1), Caitlin Orr PhD (1,2), Daniel Lee MD, MS (3,4), Susan Domchek MD (1,2,5), Kara Maxwell MD, PhD (1,2,3,5)
 

^{(1) Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 
(2) Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 
(3) Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA 
(4) Division of Surgery, University of Pennsylvania Health System, Philadelphia, PA 
(5) Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA}

POSTER 9

BRCA2 Function Modified by Mutations in the BRC Element
 

Jeanette H. Sutherland (1), Gary E. Xavier Valdez (1), William K. Holloman (2)
 

^{(1) State University of New York, Farmingdale
(2) Weill Cornell Medicine}

POSTER 10

Molecular Signature Change from Premalignancy to Malignancy in a BRCA1,Trp53-Mutated Mouse Genetic Mosaic Model for TNBC
 

Xian Zhou (1), Riddick Alexys (1), Yan Ze (2), Hu Sheng'en (2), Hui Zong (1)
 

^{(1) University of Virginia, Department of Microbiology, Immunology, and Cancer Biology
(2) University of Virginia,  Department of Genome Sciences}

POSTER 11

A Cohesin-Dependent TLS Switch Safeguards Genome Replication in BRCA2-Deficient Cells
 

Satheesh K Sengodan (1), Riley Metcalfe (1), Kajal Biswas (1), Sandra Burkett (1), Ping Zhang (1), Shyam K Sharan (1)
 

^{(1) National Cancer Institute, Frederick , MD}

POSTER 12

De Novo Design of BRCA1-BARD1 Stabilizers
 

Sanim Rahman (1), Tao Shi (1), Jonathan A. Mehrotra (1), Carman Man-Chung Li (1), Joseph M. Salvino (2), Roger A. Greenberg (1)
 

^{(1) Perelman School of Medicine at the University of Pennsylvania 
(2) The Wistar Institute}

POSTER 13

Microenvironmental Effects of BRCA2 Haploinsufficiency on Chromosome Loss Processes and Immune Signaling in 2D and 3D Tumoroids
 

Jude B. Khatib (1), Tristan Marchena (1), Dennis E. Discher (1)
 

^{(1) University of Pennsylvania,  Department of Chemical and Biomolecular Engineering}

POSTER 14

Targeting Cyclin K-CDK12 Synergizes with ATR Inhibition by Limiting RPA Chromatin Loading in Triple-Negative Breast Cancer
 

Eunbee Choi (1), Sophia Podeszwa (1), Ah-Ram Kim (2), Ashwani Bahl (3), Geoffrey I. Shapiro (1)
 

^{(1) Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
(2) Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA 
(3) Carrick Therapeutics, Dublin, Ireland}

POSTER 15

Nucleotide Excision Repair Deficiency Identified by Mutational Signatures Predicts Platinum Sensitivity in Triple-Negative Breast Cancer
 

Zsofia Sztupinszki (1,2), Judit Borcsok (2), Miklos Diossy (1), Aurel Prosz (2), Erica Mayer (3), Heather A. Parsons (4,5), Erica Stringer-Reasor (6), Vandana G. Abramson (7), Shannon L. Huggins-Puhalla (8), Daniel P. Silver (9), Antonio C. Wolff (10), Kent W. Mouw (11), Andrea L. Richardson (12), Zoltan Szallasi (1,2,13)
 

^{(1) Computational Health Informatics Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.  
(2) Danish Cancer Institute, Copenhagen, Denmark  
(3) Breast Oncology Program, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA  
(4) Fred Hutchinson Cancer Center, Seattle, WA 
(5) Division of Hematology and Oncology, University of Washington School of Medicine, Seattle, WA  
(6) O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA  
(7) Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA 
(8) UPMC Hillman Cancer Center, Pittsburgh, PA, USA  
(9) Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA  
(10) Johns Hopkins Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA  
(11) Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA  
(12) Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA  
(13) Department of Bioinformatics, Semmelweis University, Budapest, Hungary}

POSTER 16

The BRCA1-A Complex Restricts Replication Fork Reversal-Dependent DNA Repair in ATM Deficient Cells
 

Arindam Datta (1), Jessica Jackson (2), Yaroslav I Morozov (1), Jinghan Qiu (1), Alessandro Vindigni (2), Roger A. Greenberg (1)
 

^{(1) Department of Cancer Biology, Penn Center for Genome Integrity, Basser Center for BRCA,  Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
(2) Division of Oncology, Washington University, St. Louis, MO 63110}

POSTER 17

Preclinical Evaluation of PARP-targeted Theranostic Agent for Cancer Therapy
 

Sai Preethi Nakkina (1,2), Alastair McArthur (1,2), Aladdin Riad (1), Hasan Babazada (1), Mingyu Zhang (1,2), Sergey Medvedev (2), Mathew J. Anderson (2), Fiona Simpkins (2), David Mankoff (1), Robert H. Mach (1), Michael D. Farwell (1), Sarah B. Gitto (1,2)
 

^{(1) Department of Radiology, Perelman School of Medicine, University of Pennsylvania  
(2) Penn Ovarian Cancer Research Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA 19104 USA}

POSTER 18

Chemical Proteomics Reveals PARP10 as a Non Canonical Target of the PARP1 Selective Inhibitor Saruparib
 

Thales C Nepomuceno (1), Lindsey Nguy (1,2) Rachael H Martin (1), Ou Deng (3), Lancia Darville (4), John Koomen (5), Uwe Rix (3), Mian M Shahzad (2), Alvaro Monteiro (1)
 

^{(1) Moffitt Cancer Center, Cancer Epidemiology, Tampa, FL   
(2) Moffitt Cancer Center, Gynecologic Oncology, Tampa, FL   
(3) Moffitt Cancer Center, Drug Discovery, Tampa, FL   
(4) Moffitt Cancer Center, Proteomics & Metabolomics Core, Tampa, FL   
(5) Moffitt Cancer Center, Molecular Oncology, Tampa, FL}

POSTER 19

High-Throughput Mapping of 6,888 RAD51D Variants Identifies Distinct Biochemical Functions Needed for Homologous Recombination and Olaparib Response
 

Kristie E. Darrah (1,*), Shelby L. Hemker (2,*), Yashpal Rawal (4,*), Noah J. Goff (1,*), Phoebe S. Parker (1), Gayatri S. Ganesan (1), Caleb M. Stratton (4), Katherine Oppenheimer (5), Ella Roberts (5), Elena Glick (2), Nicole Banks (1), Arjun Kumar (1), Silvia Casadei (7,8), Matthew W. Snyder (7,8), Katherine Nathanson (6), Susan M. Domchek (6), Lea M. Starita (7,8), Shaun K. Olsen (4,#), Patrick Sung (4,#), Jacob O. Kitzman (2,3,#), Kara A. Bernstein (1,#)
 

^{(1) Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA    
(2) Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA    
(3) Gilbert S. Omenn Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA    
(4) Department of Biochemistry and Structural Biology and Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA    
(5) Department of Pharmacology and Chemical Biology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA   
(6) Department of Medicine, Basser Center for BRCA, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA    
(7) Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA    
(8) Brotman Baty Institute, Seattle, WA 98195, USA    
*These authors contributed equally 
#Correspondence}

POSTER 20

DNA Repeat Transcription as a Strategy to Sensitize BRCA1-Deficient Breast and Ovarian Cancers to ATR Inhibition
 

Azin Aghamajidi (1,*), Muzaffer Kassab (1,*), Rahul S. Mandal (1,*), Chandan Das (1,*), Nishita Shastri (2), Lewis A. Chodosh (1), Irfan A. Asangani (1), and Eric J. Brown (1) 
 

^{(1) Abramson Family Cancer Research Institute and Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104  
(2) BreakSight, Inc., 7540 Windsor Drive, Suite 210, Allentown, PA, 18106
*Contributed equally}

POSTER 21

Prospective Cohort Study with a Biobank for Hereditary Tumor Syndromes in Japanese -The Mid-West Japan Hereditary Tumor Cohort Study-
 

Akira Hirasawa (1)
 

^{(1) Department of Clinical Genomic Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, The Mid-West Japan Hereditary Tumor Cohort Study Group}

POSTER 22

The Relationship Between Neuroendocrine Tumors and Cowden Syndrome
 

Susan Miller-Samuel (1), Alison Greidinger (2), Veda N Giri (3), Michele Sue-Ann Woo (4), Saranya Akumalla (5), Charnita Zeigler-Johnson (6), Scott W Keith (7), Daniel P Silver (8)
 

^{(1) Cancer Risk Assessment and Clinical Cancer Genetics Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
(2) Cooper University Hospital, Cooper Medical School of Rowan University, Camden, NJ
(3) Yale School of Medicine and Clinical Cancer Genetics for Yale Cancer Center and Smilow Cancer Hospital, New Haven CT
(4) Foundation Medicine, Cambridge, MA
(5) LabCorp / INVITAE, San Francisco, CA
(6) Fox Chase Cancer Center / Temple University, Philadelphia, PA
(7) Department of Pharmacology and Experimental Therapeutics, Division of Biostatistics Thomas Jefferson University, Philadelphia, PA
(8) Department of Medical Oncology and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA}

POSTER 23

Gastric Epithelial Haploinsufficiency in BRCA1and BRCA2 Carriers Leads to Increased Double-Stranded DNA Damage
 

Kole H. Buckley (1), Michaela E. Dungan (1), Kevin Dinh (1), Gregory M. Kelly (2), Ryan Hausler (2), Kate E. Bennett (1), Daniel G. Clay (1), Julia E. Youngman (1), Ariana D. Majer (1), Keely A. Beyries (1), Blake A. Niccum (1), Sydney M. Shaffer (3,4), Tatiana A. Karakasheva (5), Kathryn E. Hamilton (5,6), Michael L. Kochman (1), Gregory G. Ginsberg (1), Nuzhat Ahmad (1), Kara N. Maxwell (2), Bryson W. Katona (1)
 

^{(1) Division of Gastroenterology and Hepatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 
(2) Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  
(3) Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA 
(4) Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA  
(5) Division of Gastroenterology, Hepatology and Nutrition; Department of Pediatrics; Children's Hospital of Philadelphia; University of Pennsylvania, Philadelphia, PA, USA
(6) Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA}

POSTER 24

The Risk of Gastrointestinal Cancer in Women with a BRCA1 or BRCA2 Mutation
 

Bryson W. Katona (1), Steven A. Narod (2, 3), and the Hereditary Breast Cancer Clinical Study Group
 

^{(1) Basser Center for BRCA and Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
(2) Women's College Research Institute, Toronto, Ontario, Canada
(3) Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada}

POSTER 25

The Impact of BRCA Status on Clinical Presentation and Management of Male Breast Cancer: A Single-Institution Study
 

Jasmine Phun (1), Caitlin Orr (2), Stephany Perez-Rojas (1), Oluwadamilola M. Fayanju (1), Julia Tchou (1), Leisha Elmore (1), Susan Domchek (2), Anupma Nayak (3), Kara Maxwell (2), Jennifer Zhang (1)
 

^{(1) Division of Breast Surgery, Department of Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 
(2) Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA 
(3) Department of Pathology and Laboratory, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA}

POSTER 26

Germline Genetic Testing in a Diverse Cohort of Veterans
 

Anna Desch (1), Meredith Davies (1), Lisa B. Aiello (1), Kara N. Maxwell (1,2,3)
 

^{(1) Medicine Service, Corporal Michael Crescenz VA Medical Center, Philadelphia, PA 
(2) Department of Medicine-Hematology/Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 
(3) Basser Center for BRCA, Abramson Cancer Center, Perelman School of Medicine, University of  Pennsylvania, Philadelphia, PA}

POSTER 27

Frequencies of Mosaic Variants Identified on Multi-Gene Panel Testing and in Breast, Ovarian, Prostate, and Pancreatic (BOPP) Cancer
 

Kimberly McGreevy, MS, CGC (1); Daphne Chen, MS, CGC (1); Shujuan Pan, PhD, FACMG (1); Debora Mancini-Dinardo, PhD, FACMG (1)
 

^{(1) Myriad Genetics, Salt Lake City, Utah}

POSTER 28

Characteristics of a Single-Institution Cohort of Male BRCA1/2 Carriers
 

Evelyn Milavsky (1,2), Caitlin Orr (1,2), Kaitlin Demarest (1,2,3), Arravinth Anantharajah (1,2,3), Emily Scarrow (1,2), Abigail Doucette (3), Rhonda Gillette (2), Susan Domchek (1,2,3), Kara N. Maxwell (1,2,3,4)
 

^{(1) Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
(2) Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
(3) Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
(4) Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA}

POSTER 29

Uptake of Contralateral Prophylactic Mastectomy in the Setting of ATM- and CHEK2-Associated Female Breast Cancer
 

Arravinth Anantharajah (1)
 

^{(1) Division of Hematology/Oncology, Department of Medicine and Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA}

POSTER 30

Optimal Cancer Risk Management Strategies for Female BRCA1 or BRCA2 Carriers
 

Muhammad Danyal Ahsan, MD (1,3); Isabelle R. Chandler, BA (2); Rylee McGonigle, BA (2); Emily M. Webster, MD (3); Sophia Sharaf (2); Nicole Frontera, BS (2); Xiaoyue Ma, MSc (4); Eunji Choi, PhD (5); Katerina Dodelzon, MD (6); Preethi Guniganti, MD (6); Sue Friedman, DVM (7); Allison W. Kurian, MD, MS (8,9); Melissa K. Frey, MD, MS* (2,3); Ravi N. Sharaf, MD, MS* (1,5,10)
 

^{(1) Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA  
(2) Genetics and Personalized Cancer Prevention Program, Department of Radiology, Weill Cornell Medicine, New York, NY 
(3) Division of Gynecology Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY  
(4) Division of Biostatistics, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY  
(5) Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medicine, New York, NY  
(6) Department of Radiology, Weill Cornell Medicine, New York, NY  
(7) Facing Our Risk of Cancer Empowered, Tampa, FL  
(8) Division of Oncology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA  
(9) Population Health Sciences Program, Stanford Cancer Institute, Palo Alto, CA  
(10) Division of Gastroenterology, Department of Medicine, Weill Cornell Medicine, New York, NY}

POSTER 31

Mammography Utilization and Male Breast Cancer in BRCA1/2 Carriers.
 

Meredith Davies (1), Maliha Tayeb (2,3), Jasmine Phun (8), Emily Scarrow (2,3), Evelyn Milavsky (2,3), Caitlin Orr (2,3), Roukiatou Sore (7), Heather Heather Symecko (3), Sarah Ehsan (7), Heena Desai (1), Abigail Doucette (3), Peter Gabriel (3,4), Christine Edmonds (6), Susan M. Domchek (2,3), Isla Garraway (9), Martin W. Schoen (10), Anne Marie McCarthy (3,7), Jennifer Zhang (3,8), Kara N. Maxwell (1,2,3)
 

^{(1) Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA
(2) Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
(3) Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
(4) Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
(5) Division of Translational Medicine & Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
(6) Hospital of the University of Pennsylvania, Department of Radiology;
(7) Department of Biostatistics, Epidemiology and Informatics Perelman School of Medicine, University of Pennsylvania
(8) Hospital of the University of Pennsylvania, Department of Surgery
(9) Greater Los Angeles Department of Veterans Affairs Healthcare System
(10) Veterans Affairs, St. Louis Healthcare System}

POSTER 32

Surgical Complications of Bilateral Salpingo-Oophorectomy (BSO), with and without Concurrent Hysterectomy, in Patients with Germline BRCA (gBRCA) Pathogenic Variants Undergoing Risk-Reducing Surgery
 

Victoria M. Ettorre, DO, MS (1)  Johanna D'Addario, PA-C (1)  Jasmine Nichols, MS-3 (2)  Mitchell Clark, MD (1)
 

^{(1) Yale New Haven Hospital, New Haven CT 
(2) Meharry Medical College, Nashville TN}

POSTER 33

Surgical Stopwatch: Analyzing Surgical Durations in Risk-Reducing Gynecologic Procedures​
 

Emma Mitnick, MPH (1); Alex Raghunandan, BS, (1); Tina Karimaghaie (1); Leslie Cohen, MD, (1); David Otterburn, MD (1); Lisa Newman, MD (1); Jeff Lin, MD (1); Evelyn Cantillo, MD (1); Eloise Chapman-Davis, MD (1); Ravi Sharaf, MD, MS (1); Melissa Frey, MD, MS (1)
 

^{(1) Weill Cornell Medicine}

POSTER 34

Analysis of Two Models of Genetic Testing: Point-of-Care vs Onsite Consult Service
 

Emily Scarrow (1, 2), Rosella Delgado (1), Meredith Davies (5), Anna Desch (5), Evelyn Milavsky (1,2), Caitlin Orr PhD (1,2), Jacquelyn Powers MS, LCGC (1,2,3), Kelsey Spielman MS, LCGC (1,2,3), Ryan Hausler MS (2,5) , Michael Wang (1,2), Abigail Doucette MPH (3), Lisa Aiello RN, PhD (5), Kara Maxwell MD, PhD (1,2,3,5), Daniel Lee MD, MS (4,5)
 

^{(1) Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 
(2) Basser Center for BRCA, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 
(3) Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 
(4) Division of Surgery, University of Pennsylvania Health System, Philadelphia, PA
(5) Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA}

POSTER 35

The Proportion of Adults who Meet NCCN Criteria for Germline Cancer Genetic Testing
 

Sophia I. Sharaf (1), Nicole Frontera (1), Rylee McGonigle (1), Isabel Chandler (1), Xiaoyue Ma (1), Siena Gioia (1), Johanna Goldberg (2), Melissa K. Frey (1), Muhammad Danyal Ahsan (1,3)
 

^{(1) Weill Cornell Medicine
(2) Memorial Sloan Kettering Cancer Center
(3) Department of Obstetrics and Gynecology, Perelman School of Medicine at the University of Pennsylvania}

POSTER 36

A Randomized Non-Inferiority Trial of an eHealth Delivery Alternative for Cancer Genetic Testing for Hereditary Cancer (eREACH2)
 

Lee KT (1), Egleston B (2), Fetzer D (1), Brown S (1), Domchek SM (1), Linda Fleisher (2), Wen KY (3), Wagner L (4), Roberts JS (5), Cacioppo C (1), Christiansen J (1), Howe S (1), Wood EM (1), Weinberg M (1), Karpink K (1), Selmani E (1), Feng J (1), John S (1), Mastaglio E (1), Bradbury AR (1)
 

^{(1) University of Pennsylvania
(2) Fox Chase Cancer Center  
(3) Thomas Jefferson University Hospital 
(4) University of North Carolina, Chapel Hill 
(5) University of Michigan School of Public Health}

POSTER 37

RESPECT3: A Randomized Study Evaluating Return of Actionable Genetic Research Results from the Penn Medicine Biobank
 

Anuja Rajendra Godbole (1), Elisabeth Wood (1), Brian Egleston (2), Lily Hoffman-Andrews (1), Sarah Brown (1), Sanjana Shastri (1), Justin Feng (1), Anjali Owens (1), Susan Domchek (1), Reed Pyeritz (1), Bryson W. Katona (1), Staci Kallish (1), Giorgio Sirugo (1), JoEllen Weaver (1), Linda Fleisher (2), Kuang-Yi Wen (3), Elena Elkin (4), Katherine L. Nathanson (1), Daniel J. Rader (1), Angela R. Bradbury (1)
 

^{(1) University of Pennsylvania, Philadelphia, PA, USA  
(2) Fox Chase Cancer Center, Temple University, Philadelphia, PA, USA 
(3) Thomas Jefferson University, Philadelphia, PA, USA  
(4) Columbia University, New York, NY, USA}

POSTER 38

A Randomized Controlled Trial of a Multilingual Digital Genetic Cancer Risk Assessment Tool in a Diverse Patient Population
 

Tina Karimaghaie, BA (1), Steve Lopez, BA (1), Isabelle Chandler, BA (1), Max Kirby, BA (1), Amanda Laterza Ozarowski, MS (1), Michelle Primiano, MS (1), Siena Gioia, BS (1), Enzo Bruscato, BS (1), Ravi Sharaf, MD MS (1*), Melissa Frey, MD MS (1,2*)
 

^{(1) Weill Cornell Medicine - Genetics and Personalized Cancer Prevention Program 
(2) Weill Cornell Medicine - Department of Obstetrics and Gynecology, Division of Gynecologic Oncology   
*These authors are co-senior authors.}

POSTER 39

The Uncertainty of Prevention: Decision-Making in RRSO Among Online Patient Narratives and Clinician Perspectives
 

Rashmi Acharya (1), Ramah McKay (2), Anna Jo Smith (3)
 

^{(1) University of Pennsylvania
(2) Department of History and Sociology of Science, University of Pennsylvania
(3) Department of Obstetrics and Gynecology, University of Pennsylvania Health Systems}

POSTER 40

Clinical Integration of a Patient-Facing Digital Tool for Population-Focused Hereditary Cancer Risk Screening in the Primary Care Setting
 

Enzo G. Bruscato, BS(1), Tina Karimaghaie, BA* (1), Max Kirby, BA (1), Jill M. Rieger, MD (2), Serena Mulhern, MD, MS (2), Meredith F. Lash-Dardia, MD (2), Brooke C. O'Neill, MSN, AGPCNP (3), La Kesha Barnes, BSN, RN (3), Nitisha Ponnappan, BA (1), Siena Gioia, BS (1),   Grace Pucel, BS (1), Julia Ciesielka, BS (1), Che Martin, PhD (4), Keith Hentel, MD (3), Adam R. Stracher, MD (2), Melissa K. Frey, MD, MS (1,5), Ravi N. Sharaf, MD, MS (1,6,7), Amanda Laterza Ozarowski, MS, CGC (1), Michelle Primiano, MS, CGC (1)
*Co-first author
 

^{(1) Genetics and Personalized Cancer Prevention Program, Department of Radiology, Weill Cornell Medicine   
(2) Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine
(3) Department of Radiology, Weill Cornell Medicine  
(4) Healthcare Innovation and Precision Medicine Strategy, New York Presbyterian Hospital
(5) Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Weill Cornell Medicine 
(6) Division of Gastroenterology, Department of Medicine, Weill Cornell Medicine 
(7) Division of Epidemiology, Department of Population Health Sciences, Weill Cornell Medicine}

POSTER 41

Genetic Social Work in Hereditary Cancer Care: Scalable Interventions for Longitudinal Psychosocial Support
 

Emily S. Epstein LMSW (1), Pranya Gaddipati BA (1), Sulekha Junnarkar BA (1), Tina Karimaghaie BA (1), Steve Lopez BA (1), Kate Cornelius-Schecter BA (1), Ruby Baden-Lasar BA (1), Michelle Primiano MS CGC (1), Susan Marchal LCSW (2), Ivy Song LMSW (1), Ravi N. Sharaf MD MS (1), Melissa K. Frey MD MS (1,3)
 

^{(1) Weill Cornell Medicine - Genetics and Personalized Cancer Prevention Program
(2) NewYork-Presbyterian Hospital - Outpatient Oncology
(3) Weill Cornell Medicine - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology}

POSTER 42

Pancreatic Imaging Findings of PRECEDE Consortium Participants with Pathogenic Germline Variants in Breast Cancer Susceptibility Genes (BRCA1, BRCA2, ATM, PALB2)
 

Samantha G Kasselman (1), Tiffiney R Hartman PhD MS CGC (1), Jessica M Long MS CGC (2), Kieran Hawthorne MS (3), John J Graff PhD MS (3), Fay Kastrinos MD MPH (4), Aimee L Lucas MD MS (5), Bryson W Katona MD PhD (6), and the PRECEDE Consortium
 

^{(1) Masters in Genetic Counseling Program, University of Pennsylvania, Philadelphia, PA, USA 
(2) Division of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA, USA
(3) Arbor Research Collaborative for Health, Ann Arbor, MI, USA  
(4) Division of Digestive and Liver Diseases, Columbia University, New York City, New York, USA  
(5) Division of Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA  
(6) Division of Gastroenterology and Hepatology, University of Pennsylvania, Philadelphia, PA, USA}

POSTER 43

Toward a Robust Lesion Detection Model in Breast DCE-MRI: Adapting Foundation Models to High-Risk Women
 

Gabriel A.B. do Nascimento (1,2), Vincent Dong (1), Arthur C. Costa (1), Guilherme J.  Cavalcante (1,2), Alex Nguyen (1), Thais G. do Rego (2), Yuri Malheiros (2), Telmo M. Silva Filho (3), Carla R. Zeballos Torrez (1), James C. Gee (1), Anne Marie McCarthy (1), Andrew D. A. Maidment (1),  and Bruno Barufaldi (1)
 

^{(1) University of Pennsylvania, Philadelphia, PA, US
(2) Federal University of Paraiba, Joao Pessoa, PB, Brazil
(3) University of Bristol, Bristol, UK}

POSTER 44

Basser Center for BRCA: Current Studies and Initiatives
 

Catherine Wolfe (1), Ariel Weinbaum (1), Alyzea Benjamin (1), Jamie Brower (1), Jacqueline Cappadocia (1), Jessica Dable (1), Lorraine Dugoff (2), Rose Giardine (2), Jada Hamilton (3), Samantha Pipito (1), Jacquelyn Powers (1), Susan Domchek (1)
 

^{(1) Basser Center for BRCA, University of Pennsylvania, Philadelphia PA
(2) Department of Obstetrics and Gynecology Reproductive Genetics, University of Pennsylvania, Philadelphia PA
(3) Genomics, Risk, and Health Decision-Making Laboratory, Memorial Sloan Kettering Cancer Center, New York City, NY}